You can specify the encoding in the File/Open dialog.
Unfortunately there is a bug in version 4.2.2. Here the encoding selection works on Windows XP, but not on Windows Vista and Windows Vista. This will be fixed soon. Earlier version do not have this problem.
A feature that some users might find convenient is the ability to 'reload with encoding xxx', or 'display with encoding xxx'. E.g. if you have opened a file from the sidebar, where you don't get to specify the encoding, and SuperEdi doesn't guess it correctly.